Denis Grandgirard Selected Research

batimastat (BB 94)

7/2020	Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy.
12/2014	Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis.

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Denis Grandgirard Research Topics

Disease

30	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 01/2022 - 05/2003
24	Infections 01/2022 - 06/2007
14	Inflammation (Inflammations) 01/2020 - 05/2003
11	Meningitis 01/2022 - 01/2009
11	Brain Injuries (Brain Injury) 07/2020 - 04/2006
9	Bacterial Meningitis 10/2014 - 04/2006
6	Neuroinflammatory Diseases 01/2022 - 08/2018
6	Hearing Loss (Hearing Impairment) 07/2019 - 08/2012
5	Meningococcal Meningitis 07/2020 - 04/2006
5	Body Weight (Weight, Body) 01/2020 - 06/2007
5	Heart Arrest (Cardiac Arrest) 01/2020 - 01/2015
3	Pneumonia (Pneumonitis) 01/2022 - 11/2019
3	Multiple Sclerosis 01/2022 - 07/2008
3	Pneumococcal Infections 01/2020 - 01/2016
3	Necrosis 07/2019 - 03/2015
3	Weight Loss (Weight Reduction) 01/2019 - 04/2014
2	Brain Ischemia (Cerebral Ischemia) 01/2022 - 01/2020
2	Ventilator-Associated Pneumonia 09/2021 - 11/2019
2	Alveolar echinococcosis 01/2021 - 05/2015
2	Neointima 01/2021 - 10/2019
2	Thrombosis (Thrombus) 01/2021 - 10/2019
2	Neoplasms (Cancer) 01/2021 - 01/2005
2	Aneurysm (Aneurysms) 01/2021 - 10/2019
2	Tick-Borne Encephalitis (Encephalitis, Tick Borne) 01/2017 - 01/2012
1	Ischemic Stroke 01/2022
1	COVID-19 01/2022
1	Stroke (Strokes) 01/2022
1	Autosomal Recessive 2 Spinocerebellar Ataxia 01/2021
1	Bacterial Infections (Bacterial Infection) 01/2020
1	Intracranial Aneurysm (Cerebral Aneurysm) 10/2019
1	Communicable Diseases (Infectious Diseases) 08/2019
1	Diabetes Mellitus 07/2019

Drug/Important Bio-Agent (IBA)

15	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 04/2006
10	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2022 - 06/2007
10	CytokinesIBA 01/2022 - 07/2008
8	Matrix Metalloproteinases (MMPs)IBA 07/2020 - 01/2013
7	VaccinesIBA 01/2017 - 01/2005
7	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2011
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 05/2003
6	Daptomycin FDA Link 09/2021 - 06/2007
5	Interleukin-6 (Interleukin 6)IBA 03/2016 - 01/2013
4	AntigensIBA 01/2022 - 10/2009
4	Matrix Metalloproteinase InhibitorsIBA 07/2020 - 01/2014
4	Pharmaceutical PreparationsIBA 07/2019 - 03/2015
4	Dexamethasone (Maxidex)FDA LinkGeneric 08/2018 - 04/2006
3	Biomarkers (Surrogate Marker)IBA 10/2020 - 12/2014
3	Neuroprotective AgentsIBA 07/2020 - 01/2018
3	EnzymesIBA 03/2015 - 06/2008
2	batimastat (BB 94)IBA 07/2020 - 12/2014
2	Doxycycline (Periostat)FDA LinkGeneric 07/2020 - 01/2019
2	ChemokinesIBA 01/2020 - 07/2013
2	Metalloproteases (Metalloproteinases)IBA 08/2019 - 01/2014
2	Potassium Chloride FDA LinkGeneric 04/2016 - 01/2015
2	esmolol (Brevibloc)FDA LinkGeneric 04/2016 - 01/2015
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 07/2013 - 01/2013
2	Caspase 3 (Caspase-3)IBA 02/2013 - 05/2003
2	salicylhydroxamic acid (SHAM)IBA 03/2011 - 01/2009
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2010 - 06/2007
1	endolysinIBA 01/2022
1	AntibodiesIBA 01/2022
1	AutoantigensIBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	InterleukinsIBA 01/2022
1	Phosphates (Orthophosphate)IBA 01/2022
1	Vancomycin FDA LinkGeneric 01/2022
1	Interleukin-8 (Interleukin 8)IBA 01/2022
1	Interleukin-1beta (Interleukin 1 beta)IBA 01/2022
1	Neutralizing AntibodiesIBA 01/2022
1	Therapeutic UsesIBA 09/2021
1	SugarsIBA 01/2021
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2021
1	Green Fluorescent ProteinsIBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Tetracycline (Achromycin)FDA LinkGeneric 07/2020
1	GTP-Binding Proteins (G-Protein)IBA 01/2020
1	Ethanol (Ethyl Alcohol)IBA 01/2020
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2020
1	1,1-dimethylbutyl-1-deoxy-Delta(9)-THCIBA 01/2020
1	TeicoplaninIBA 11/2019
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2019
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2019
1	Metformin (Glucophage)FDA LinkGeneric 07/2019
1	BiguanidesIBA 07/2019
1	PerforinIBA 05/2019
1	CholesterolIBA 05/2019
1	Streptococcus pneumoniae plY proteinIBA 05/2019
1	alpha-Crystallin B ChainIBA 01/2019
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2019
1	Small Heat-Shock ProteinsIBA 01/2019
1	Sialic AcidsIBA 01/2019

Therapy/Procedure

20	Therapeutics 09/2021 - 01/2005
3	Phage Therapy 01/2022 - 11/2019
2	Stents 01/2021 - 10/2019
2	Resuscitation 01/2020 - 04/2016
1	Intraperitoneal Injections 01/2022
1	Immunomodulation 01/2022
1	Transcranial Magnetic Stimulation 01/2020
1	Induced Heart Arrest (Cardioplegia) 01/2020
1	Transplantation 01/2020